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KMID : 0384119910110010207
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Korean Journal of Clinical Pathology
1991 Volume.11 No. 1 p.207 ~ p.214
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A Study on Hepatitis C Virus Antibody (anti-HCV) in Healthy Blood Donors and Patients with type b and NANB Acute Hepatitis and Chronic Liver Disease
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J. N. Lee. E. J. Hwang
J. R. Jo/K. J. Hahm/E. Y. Lee/H. C. Son/S. H. Kim
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Abstract
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In order to elucidate prevalence of the hepatitis C viral antibody (anti-HCV) in blood donors and liver diseases, the author examined serum anti-HCV in 600 cases of blood donors, 74 cases of non-A, non-B(NANB) liver disease and 77 cases of type B liver diseses using HCV EIA kit of Abbott. Diagnosis were established on the basis of commonly accepted clinical, serimmunological and histopathological criteria. All blood was obtained from veins of the blood donors and patients at Pusan Paik Hospital and some Hospitals during the period of May to August, 1990. The results obtained were summarized as follows : 1. The serum anti-HCV was detected in 4 of 600 (0.67 % ) healthy blood donors. 2. The pervalence of serum anti-HCV was 25.0% (l/4) in NANB acute hepatitis, 37.0% (10/27) in NANB chronic hepatitis, 26.9 % (7/26) in NANB liver cirrhosis and 35.3 % (6/17) in NANB hepatocellular carcinoma, respectively. 3. The prevalence of serum anti-HCV was 4.0 % (l/25) in chronic hepatitis type B, 4.8% (l/21) in liver cirrhosis type B and 5.3% (l/19) in hepatocellular carcinoma type B respectively. The prevalence of serum anti-HCV tended to be increased as the pathological changes of liver tissue was advanced in chronic liver diseases type B. 4. The pervalence of serum anti-HCV was significantly higher in NANB liver disease than that in liver disease type B. On the basis of the results above, it can be suggested that the serum anti-HCV is a useful serological markers in acute hepatitis and chronic liver diseases type C.
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